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Cefoperazone injection

What is cefoperazone injection?

CEFOPERAZONE (Cefobid®) is a cephalosporin antibiotic. It treats many kinds of infections, including those of the skin, bone, stomach, respiratory tract, sinuses, blood, and urinary tract. Cefoperazone also treats some sexually transmitted disease. Generic cefoperazone injections are available.

What should my health care professional know before I receive cefoperazone?

They need to know if you have any of these conditions:

  • an alcohol abuse problem

  • bleeding problems

  • liver disease

  • stomach or intestinal problems (especially colitis)

  • other chronic illness

  • an unusual or allergic reaction to cefoperazone, other cephalosporin antibiotics, penicillin, penicillamine, other foods, dyes or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Cefoperazone is for injection into a muscle or for infusion into a vein. Follow the directions on the prescription label. Use your doses at regular intervals. Do not use your medicine more often than directed. Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop using except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What drug(s) may interact with cefoperazone?

  • agents that dissolve blood clots

  • alcohol

  • blood thinners

  • certain antibiotics given by injection

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking cefoperazone?

Tell your prescriber or health care professional if your symptoms do not begin to improve in a few days.

If you are diabetic you may get a false-positive result for sugar in your urine. Check with your prescriber or health care professional before you change your diet or the dose of your diabetic medicine.

If you get severe or watery diarrhea, do not treat yourself. Call your prescriber or health care professional for advice.

If you are being treated for a sexually transmitted disease, avoid sexual contact until you have finished your treatment. Having sex can infect your sexual partner.

Avoid alcoholic drinks while you are using cefoperazone and for two days afterwards. Alcohol may give you a headache, make you dizzy, feel sick, sweat and increase your heartbeat. Other medicines you get on prescription, or buy at the pharmacy may contain small amounts of alcohol.

What side effects may I notice from receiving cefoperazone?

Side effects that you should report to your prescriber or health care professional as soon as possible:

  • difficulty breathing, wheezing

  • dizziness

  • headache

  • fever or chills, sore throat

  • redness, blistering, peeling or loosening of the skin, including inside the mouth

  • seizures (convulsions)

  • severe or watery diarrhea

  • skin rash, itching

  • stomach pain or cramps

  • swollen joints

  • unusual bleeding or bruising

  • unusual tiredness or weakness

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • diarrhea

  • nausea, vomiting

  • pain, swelling and irritation at the injection site (with injection into a muscle)

Where can I keep my medicine?

Keep out of the reach of children.

Store the dry powder for injection below 25 degrees C (77 degrees F). Protect from light. Follow manufacturers advice on storage of diluted solutions. Throw away any unused portions. Protection from light is not necessary. Do not use if solution is cloudy or particulate matter is present.

Publication Source: U.S. FDA-approved Package Insert
Date Last Modified: 9/18/2006